Cytotoxic and antigen presenting functions of T helper-1-activated dendritic cells.
Fiche publication
Date publication
juillet 2012
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BONNOTTE Bernard
Tous les auteurs :
Larmonier N, Bonnotte B, Katsanis E
Lien Pubmed
Résumé
Although primarily defined by their cardinal antigen-presenting function, dendritic cells (DCs) are also equipped with cytotoxic properties. We have recently reported that DCs activated by IFNgamma-secreting Th-1 lymphocytes can kill cancer cells and subsequently present the acquired tumor-derived antigens to T lymphocytes both in vitro and in vivo.
Référence
Oncoimmunology. 2012 Jul 1;1(4):566-568.