Hydrogels incorporating GdDOTA: towards highly efficient dual T1/T2 MRI contrast agents.
Fiche publication
Date publication
septembre 2012
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ANDRY Marie-Christine
Tous les auteurs :
Courant T, Roullin VG, Cadiou C, Callewaert M, Andry MC, Portefaix C, Hoeffel C, de Goltstein MC, Port M, Laurent S, Elst LV, Muller R, Molinari M, Chuburu F
Lien Pubmed
Résumé
Do not tumble dry: Gadolinium-DOTA encapsulated into polysaccharide nanoparticles (GdDOTA NPs) exhibited high relaxivity (r(1) =101.7 s(-1) mM(-1) per Gd(3+) ion at 37 degrees C and 20 MHz). This high relaxation rate is due to efficient Gd loading, reduced tumbling of the Gd complex, and the hydrogel nature of the nanoparticles. The efficacy of the nanoparticles as a T(1)/T(2) dual-mode contrast agent was studied in C6 cells.
Référence
Angew Chem Int Ed Engl. 2012 Sep 3;51(36):9119-22