Vesicular Structures Self-Assembled from Oligonucleotide-Polymer Hybrids: Mechanical Prevention of Bacterial Colonization Upon their Surface Tethering Through Hybridization.
Fiche publication
Date publication
décembre 2012
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ANSELME Karine
Tous les auteurs :
Cottenye N, Anselme K, Ploux L, Vebert-Nardin C
Lien Pubmed
Résumé
In order to design soft coatings, surface tethering of vesicular structures self-assembled from oligonucleotide-polymer hybrids is achieved through hybridization. Watson-Crick base-pairing occurs between the nucleotide sequences involved in the self-assembly and their surface-tethered complementary sequences. Combining the quartz crystal microbalance and in situ observations using confocal laser scanning microscopy, it is evidenced that the vesicles retain their morphology even under flow stress. Surprisingly, these soft surfaces prevent bacterial colonization.
Référence
Adv Funct Mater. 2012 Dec 5;22(23):4891-8.