Encapsulation of contrast imaging agents by polypropyleneimine-based dendrimers.
Fiche publication
Date publication
mars 2013
Auteurs
Membres identifiés du Cancéropôle Est :
Dr NUZILLARD Jean-Marc, Dr OUDART Jean-Baptiste
Tous les auteurs :
Balieu S, Cadiou C, Martinez A, Nuzillard JM, Oudart JB, Maquart FX, Chuburu F, Bouquillon S
Lien Pubmed
Résumé
Polypropyleneimines (PPIs) functionalized by glycerol-based entities are prepared and characterized by diffusion-ordered spectroscopy NMR. Showing low cytotoxicity against MRC5 fibroblasts, their encapsulation capacities of gadolinium complexes was evaluated. T(1) measurements were performed to determine the relaxivity of the encapsulated gadopentetate dimeglumine (GdBOPTA) in dendrimers of fourth and fifth generation (GD-PPI-4 and GD-PPI-5). Comparison of the GdBOPTA relaxivity and the relaxivity of GdBOPTA-loaded dendrimers showed a slight increase of the gadolinium chelate relaxivity.
Référence
J Biomed Mater Res A. 2013 Mar;101(3):613-21