A novel copper(II) mononuclear complex with the non-steroidal anti-inflammatory drug diclofenac: structural characterization and biological activity.
Fiche publication
Date publication
mars 2013
Auteurs
Membres identifiés du Cancéropôle Est :
Pr TARPIN Michel
Tous les auteurs :
Sayen S, Carlier A, Tarpin M, Guillon E
Lien Pubmed
Résumé
A copper(II) complex with the non-steroidal anti-inflammatory drug (NSAID) diclofenac has been for the first time synthesized and characterized without any co-organic ligand. Its biological activity against four human cell lines underlined a higher activity of the monomeric complex than the parent molecule in the case of tumoral cell lines. A ternary Cu-diclofenac-albumin complex was suspected to be the reactive species in biological medium.
Référence
J Inorg Biochem. 2013 Mar;120:39-43