Intracranial hemorrhage caused by dabrafenib and trametinib therapy for metastatic melanoma.
Fiche publication
Date publication
avril 2024
Journal
Melanoma research
Auteurs
Membres identifiés du Cancéropôle Est :
Pr AUBIN François, Dr NARDIN Charlée
Tous les auteurs :
Hennemann A, Puzenat E, Decreuse M, Vuillier F, Nardin C, Aubin F
Lien Pubmed
Résumé
Although generally well tolerated compared with chemotherapy, molecular targeted therapy used in metastatic melanoma may be associated with life-threatening toxicity. We report the case of a patient with metastatic melanoma treated by dabrafenib plus trametinib who developed intracranial hemorrhage. Physicians should be aware of this rare but life-threatening adverse event of B-rapidly accelerated fibrosarcoma (BRAF) and mitogen-activated protein kinase kinase (MEK). However, they should be careful about the bleeding origin, which can prove to be a new onset of melanoma metastasis or anticoagulation overdose, or even an uncontrolled arterial hypertension.
Référence
Melanoma Res. 2024 04 5;: