Telomere Dysfunction in Pediatric Patients with Differences/Disorders of Sexual Development.
Fiche publication
Date publication
mars 2024
Journal
Biomedicines
Auteurs
Membres identifiés du Cancéropôle Est :
Dr JEANDIDIER Eric
Tous les auteurs :
Younoussa H, Gadji M, Soumboundou M, Colicchio B, Said A, Ndoye NA, Junker S, Plesch A, Heidingsfelder L, Diagne NR, Dieterlen A, Voisin P, Carde P, Jeandidier E, M'kacher R
Lien Pubmed
Résumé
Differences/Disorders of sex development (DSDs) are conditions in which the development of chromosomal, gonadal, and anatomical sexes is atypical. DSDs are relatively rare, but their incidence is becoming alarmingly common in sub-Saharan Africa (SSA). Their etiologies and mechanisms are poorly understood. Therefore, we have investigated cytogenetic profiles, including telomere dysfunction, in a retrospective cohort of Senegalese DSD patients.
Mots clés
DSDs, chromosomal aberrations, telomere dysfunctions, telomere shortening
Référence
Biomedicines. 2024 03 2;12(3):