TLRs1-10 Protein Expression in Circulating Human White Blood Cells during Bacterial and COVID-19 Infections.
Fiche publication
Date publication
mars 2024
Journal
Journal of innate immunity
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MAUVIEUX Laurent, Dr MIGUET Laurent
Tous les auteurs :
Chomel L, Vogt M, Demiselle J, Le Borgne P, Tschirhart M, Morandeau V, Merdji H, Miguet L, Helms J, Meziani F, Mauvieux L
Lien Pubmed
Résumé
Toll-like receptors play crucial roles in sepsis-induced systemic inflammatory response. Septic shock mortality correlates with overexpression of neutrophilic TLR2 and TLR9, while the role of TLR4 overexpression remains a debate. In addition, TLRs are involved in the pathogenesis of viral infections such as COVID-19, where the single-stranded RNA of SARS-CoV-2 is recognized by TLR7 and TLR8, and the spike protein activates TLR4.
Référence
J Innate Immun. 2024 03 8;: