PI3K signaling in the locus coeruleus: a new molecular pathway for ADHD research.
Fiche publication
Date publication
juillet 2015
Journal
EMBO molecular medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DARCQ Emmanuel
Tous les auteurs :
Darcq E, Kieffer BL
Lien Pubmed
Résumé
Attention-deficit/hyperactivity disorder (ADHD) is a developmental disorder characterized by hyperactivity, inattention, and impulsive behaviors and has significant societal impact. ADHD is recognized as a heterogeneous disease, and genetic and/or environmental factors underlying pathogenesis remain largely unknown. There is an obvious need to increase knowledge on molecular signaling and brain pathways underlying disease development, and genetic mouse models are key to this goal. In this issue of , D'Andrea (2015) combine state-of-the-art genetic and behavioral approaches in the mouse to demonstrate an essential role for PI3Kγ and cAMP homeostasis in ADHD-related behaviors, through signaling mechanisms operating at the level of the locus coeruleus, the main source of noradrenaline in the brain. Furthermore, the study posits PI3Kγ knockout mice as a novel tool of high interest for modeling ADHD endophenotypes.
Mots clés
Adrenergic Neurons, pathology, Animals, Attention Deficit Disorder with Hyperactivity, pathology, Class Ib Phosphatidylinositol 3-Kinase, metabolism, Cyclic AMP Response Element-Binding Protein, metabolism, Cyclic Nucleotide Phosphodiesterases, Type 4, metabolism, Locus Coeruleus, pathology, Signal Transduction
Référence
EMBO Mol Med. 2015 07;7(7):859-61