Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks.
Fiche publication
Date publication
août 2018
Journal
Biological psychiatry
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DARCQ Emmanuel
Tous les auteurs :
Ben Hamida S, Mendonça-Netto S, Arefin TM, Nasseef MT, Boulos LJ, McNicholas M, Ehrlich AT, Clarke E, Moquin L, Gratton A, Darcq E, Harsan LA, Maldonado R, Kieffer BL
Lien Pubmed
Résumé
Alcohol use disorder (AUD) is devastating and poorly treated, and innovative targets are actively sought for prevention and treatment. The orphan G protein-coupled receptor GPR88 is enriched in mesocorticolimbic pathways, and Gpr88 knockout mice show hyperactivity and risk-taking behavior, but a potential role for this receptor in drug abuse has not been examined.
Mots clés
Amygdala, Ethanol voluntary drinking, Gpr88 knockout mice, Operant self-administration, Orphan G protein–coupled receptor, Prefrontal cortex, Resting-state functional magnetic resonance imaging, Ventral tegmental area
Référence
Biol Psychiatry. 2018 08 1;84(3):202-212