Chronic tianeptine induces tolerance in analgesia and hyperlocomotion via mu-opioid receptor activation in mice.
Fiche publication
Date publication
mai 2023
Journal
Frontiers in psychiatry
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DARCQ Emmanuel
Tous les auteurs :
Allain F, Ehrlich AT, McNicholas M, Gross F, Ma W, Kieffer BL, Darcq E
Lien Pubmed
Résumé
Tianeptine is approved in some countries to treat depression and anxiety. In addition to its activity on serotonin and glutamate neurotransmission, tianeptine has been proven to be a mu-opioid receptor (MOR) agonist, but only a few preclinical studies have characterized the opioid-like behavioral effects of tianeptine.
Mots clés
locomotor activity, mu-opioid receptor (MOR), opioid, place preference, tail immersion, tianeptine
Référence
Front Psychiatry. 2023 05 23;14:1186397