Habenular Neurons Expressing Mu Opioid Receptors Promote Negative Affect in a Projection-Specific Manner.
Fiche publication
Date publication
juin 2023
Journal
Biological psychiatry
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DARCQ Emmanuel
Tous les auteurs :
Bailly J, Allain F, Schwartz E, Tirel C, Dupuy C, Petit F, Diana MA, Darcq E, Kieffer BL
Lien Pubmed
Résumé
The mu opioid receptor (MOR) is central to hedonic balance and produces euphoria by engaging reward circuits. MOR signaling may also influence aversion centers, notably the habenula (Hb), where the receptor is highly dense. Our previous data suggest that the inhibitory activity of MOR in the Hb may limit aversive states. To investigate this hypothesis, we tested whether neurons expressing MOR in the Hb (Hb-MOR neurons) promote negative affect.
Mots clés
Anxiety, Avoidance, Despair-like behavior, Habenula circuitry, Opioids, Optogenetics
Référence
Biol Psychiatry. 2023 06 15;93(12):1108-1117