Vacuolization of hematopoietic precursors: an enigma with multiple etiologies.
Fiche publication
Date publication
juillet 2021
Journal
Blood
Auteurs
Membres identifiés du Cancéropôle Est :
Dr PAGLIUCA Simona
Tous les auteurs :
Gurnari C, Pagliuca S, Durkin L, Terkawi L, Awada H, Kongkiatkamon S, Zawit M, Hsi ED, Carraway HE, Rogers HJ, Visconte V, Maciejewski JP
Lien Pubmed
Résumé
Cytoplasmic vacuoles in precursors can be seen in a number of clinical settings, including copper deficiency, zinc toxicity, alcohol abuse, antibiotic treatment, myelodysplasia, and VEXAS syndrome. Gurnari et al asked how common VEXAS syndrome is in patients whose bone marrow aspirates show this distinctive feature, finding 2 diagnoses of VEXAS among 24 cases with vacuoles.
Mots clés
Adult, Aged, Aged, 80 and over, Bone Marrow Cells, enzymology, Child, Erythroid Cells, enzymology, Female, Genes, X-Linked, Humans, Male, Middle Aged, Mutation, Myeloid Cells, enzymology, Myeloid Progenitor Cells, enzymology, Myeloproliferative Disorders, enzymology, Syndrome, Ubiquitin-Activating Enzymes, genetics, Vacuoles, enzymology
Référence
Blood. 2021 07 1;137(26):3685-3689