Molecules interact. But how strong and how much?
Fiche publication
Date publication
juin 2023
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GOGL Gergo
Tous les auteurs :
Weimer K, Zambo B, Gogl G
Lien Pubmed
Résumé
Interactomics aims to characterize all interactions formed between molecules that comprise our body. Although it emerged from quantitative biophysics, it has devolved into a predominantly qualitative field of science over the past decades. Due to technical limitations at its onset, almost all tools in interactomics are qualitative, which persists in defining the discipline. Here, we argue that interactomics needs to return to a quantitative direction because the technical achievements of the last decade have overcome the original limitations that forced its current path. In contrast to qualitative interactomics which is constrained to charting lists of observed interactions, quantitative interactomics can also uncover answers to key questions such as the strength of interactions or how many of certain complexes can form in cells, thus providing researchers with more immediate proxies for understanding and predicting biological processes.
Mots clés
interactomics, protein-protein interactions, quantitative biology
Référence
Bioessays. 2023 06;45(6):e2300007