Prediction, screening and characterization of novel bioactive tetra-peptide matrikines for skin rejuvenation.
Fiche publication
Date publication
février 2024
Journal
The British journal of dermatology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DEBELLE Laurent
Tous les auteurs :
Jariwala N, Ozols M, Eckersley A, Mambwe B, Watson REB, Zeef L, Gilmore A, Debelle L, Bell M, Bradley EJ, Doush Y, Keenan A, Courage C, Leroux R, Peschard O, Mondon P, Ringenbach C, Bernard L, Pitois A, Sherratt MJ
Lien Pubmed
Résumé
Extracellular matrices play a critical role in tissue structure and function and aberrant remodelling of these matrices is a hallmark of many age-related diseases. In skin, loss of dermal collagens and disorganisation elastic fibre components are key features of photo-ageing. Although application of some small matrix-derived peptides to aged skin has been shown to beneficially affect in vitro cell behaviour and, in vivo, molecular architecture and clinical appearance, the discovery of new peptides has lacked a guiding hypothesis.
Référence
Br J Dermatol. 2024 02 20;: