The Multifaceted Role of Human Dickkopf-3 (DKK-3) in Development, Immune Modulation and Cancer.
Fiche publication
Date publication
décembre 2023
Journal
Cells
Auteurs
Membres identifiés du Cancéropôle Est :
Dr JUNG Alain, Dr WASYLYK Bohdan
Tous les auteurs :
Mourtada J, Thibaudeau C, Wasylyk B, Jung AC
Lien Pubmed
Résumé
The human Dickkopf (DKK) family includes four main secreted proteins, DKK-1, DKK-2, DKK-3, and DKK-4, as well as the DKK-3 related protein soggy (Sgy-1 or DKKL1). These glycoproteins play crucial roles in various biological processes, and especially modulation of the Wnt signaling pathway. DKK-3 is distinct, with its multifaceted roles in development, stem cell differentiation and tissue homeostasis. Intriguingly, DKK-3 appears to have immunomodulatory functions and a complex role in cancer, acting as either a tumor suppressor or an oncogene, depending on the context. DKK-3 is a promising diagnostic and therapeutic target that can be modulated by epigenetic reactivation, gene therapy and DKK-3-blocking agents. However, further research is needed to optimize DKK-3-based therapies. In this review, we comprehensively describe the known functions of DKK-3 and highlight the importance of context in understanding and exploiting its roles in health and disease.
Mots clés
DKK-3, Dickkopf (DKK) family, Wnt signaling pathway, cancer, development, immunomodulation, oncogene, therapy, tumor suppressor
Référence
Cells. 2023 12 29;13(1):