A single chemotherapy administration induces muscle atrophy, mitochondrial alterations and apoptosis in breast cancer patients.
Fiche publication
Date publication
janvier 2024
Journal
Journal of cachexia, sarcopenia and muscle
Auteurs
Membres identifiés du Cancéropôle Est :
Pr PIVOT Xavier, Dr SCHOTT Roland, Dr BENDER Laura, Pr FAVRET Fabrice, Pr GENY Bernard, Dr HUCTEAU Elyse, Dr MALLARD Joris
Tous les auteurs :
Mallard J, Hucteau E, Bender L, Moinard-Butot F, Rochelle E, Boutonnet L, Grandperrin A, Schott R, Pflumio C, Trensz P, Kalish-Weindling M, Charles AL, Gény B, Favret F, Pivot X, Hureau TJ, Pagano AF
Lien Pubmed
Résumé
Breast cancer patients are commonly treated with sequential administrations of epirubicin-cyclophosphamide (EC) and paclitaxel (TAX). The chronic effect of this treatment induces skeletal muscle alterations, but the specific effect of each chemotherapy agent is unknown. This study aimed to investigate the effect of EC or TAX administration on skeletal muscle homeostasis in breast cancer patients.
Mots clés
Anthracycline-cyclophosphamide, Mitochondria, Mitochondrial respiration, Muscle biopsies, Skeletal muscle deconditioning, Taxanes
Référence
J Cachexia Sarcopenia Muscle. 2024 01 6;: