Day-to-day spontaneous social behaviours is quantitatively and qualitatively affected in a 16p11.2 deletion mouse model.
Fiche publication
Date publication
décembre 2023
Journal
Frontiers in behavioral neuroscience
Auteurs
Membres identifiés du Cancéropôle Est :
Dr HERAULT Yann
Tous les auteurs :
Rusu A, Chevalier C, de Chaumont F, Nalesso V, Brault V, Hérault Y, Ey E
Lien Pubmed
Résumé
Autism spectrum disorders affect more than 1% of the population, impairing social communication and increasing stereotyped behaviours. A micro-deletion of the 16p11.2 BP4-BP5 chromosomic region has been identified in 1% of patients also displaying intellectual disabilities. In mouse models generated to understand the mechanisms of this deletion, learning and memory deficits were pervasive in most genetic backgrounds, while social communication deficits were only detected in some models.
Mots clés
16p11.2 deletion, autism, long-term monitoring, mouse model, social behaviour, spontaneous behaviour, ultrasonic vocalisations
Référence
Front Behav Neurosci. 2023 12 19;17:1294558