Solid-state NMR spectroscopy for structural studies of polypeptides and lipids in extended physiological membranes.
Fiche publication
Date publication
mai 2023
Journal
Biochimica et biophysica acta. Biomembranes
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BECHINGER Burkhard
Tous les auteurs :
Saad A, Bechinger B
Lien Pubmed
Résumé
Solid-state NMR is a quickly developing technique that allows one to obtain structural information at atomic resolution in extended lipid bilayers in a rather unique manner. Two approaches have been developed for membrane proteins and peptides namely magic angle sample spinning and the use of uniaxially oriented membrane samples. The state-of-the-art of both approaches will be introduced and the perspectives of solid-state NMR spectroscopy in the context of other structural biology techniques, pressing biomedical questions and membrane biophysics will be discussed.
Mots clés
(1)H-detected ultrafast MAS, Dynamics, Membrane proteins, Solid-state NMR, Structural biology, Supported lipid bilayers
Référence
Biochim Biophys Acta Biomembr. 2023 05 13;:184162