A novel ΔNp63-dependent immune mechanism improves prognosis of HPV-related head and neck cancer.
Fiche publication
Date publication
octobre 2023
Journal
Frontiers in immunology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BOREL Christian, Dr GAIDDON Christian, Dr JUNG Alain, Mme LEDRAPPIER Sonia, Dr WASYLYK Bohdan, Dr MELLITZER Georg, Mme NICOL Anaïs, Dr BURGY Mickaël
Tous les auteurs :
Mourtada J, Lony C, Nicol A, De Azevedo J, Bour C, Macabre C, Roncarati P, Ledrappier S, Schultz P, Borel C, Burgy M, Wasylyk B, Mellitzer G, Herfs M, Gaiddon C, Jung AC
Lien Pubmed
Résumé
Deconvoluting the heterogenous prognosis of Human Papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OSCC) is crucial for enhancing patient care, given its rapidly increasing incidence in western countries and the adverse side effects of OSCC treatments.
Mots clés
human papillomavirus, immune response, oropharyngeal squamous cell carcinoma, tumor microenvironment, ΔNp63
Référence
Front Immunol. 2023 10 25;14:1264093