Usefulness of an RNA extraction-free test for the multiplexed detection of , , and Gene Fusions in Real Life FFPE Specimens of Non-Small Cell Lung Cancers.
Fiche publication
Date publication
octobre 2023
Journal
Expert review of molecular diagnostics
Auteurs
Membres identifiés du Cancéropôle Est :
Pr VIGNAUD Jean-Michel
Tous les auteurs :
Damiola F, Alberti L, Mansuet-Lupo A, Damotte D, Hofman V, Tixier L, Penault-Llorca F, Rouquette I, Vignaud JM, Cazes A, Forest F, Begueret H, Gibault L, Badoual C, Cayre A, Taranchon-Clermont E, Duc A, Mc Leer A, Lantuejoul S
Lien Pubmed
Résumé
, and rearrangements occur, respectively, in 5%, 2%, and 1% non-small cell lung cancers (NSCLC). ALK and ROS1 fusion proteins detection by immunohistochemistry (IHC) has been validated for rapid patient screening, but fusions need to be confirmed by another technique and no RET IHC test is available for clinical use.
Mots clés
ALK, HTG, NSCLC, RET, ROS1
Référence
Expert Rev Mol Diagn. 2023 10 31;:1-9