Association of Age-Related Macular Degeneration with a Blood Biomarker of Lipopolysaccharide, a Gut Bacterial Proinflammatory Toxin.
Fiche publication
Date publication
novembre 2023
Journal
Investigative ophthalmology & visual science
Auteurs
Membres identifiés du Cancéropôle Est :
Dr PAIS DE BARROS Jean-Paul
Tous les auteurs :
Larsen PP, Féart C, Pais de Barros JP, Merle BMJ, Gayraud L, Delyfer MN, Korobelnik JF, Delcourt C
Lien Pubmed
Résumé
Chronic inflammation, immune dysregulation, and oxidative stress are major drivers of age-related macular degeneration (AMD) pathogenesis. Lipopolysaccharide (LPS) is a potent proinflammatory toxin originating from gut bacteria. We assessed the association of a blood biomarker of LPS exposure with incident AMD.
Mots clés
Humans, Lipopolysaccharides, Gastrointestinal Microbiome, Prospective Studies, Macular Degeneration, diagnosis, Bacterial Toxins, Biomarkers
Référence
Invest Ophthalmol Vis Sci. 2023 11 1;64(14):47