MBD4 loss results in global reactivation of promoters and retroelements with low methylated CpG density.
Fiche publication
Date publication
novembre 2023
Journal
Journal of experimental & clinical cancer research : CR
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BRONNER Christian, Dr HAMICHE Ali
Tous les auteurs :
Papin C, Ibrahim A, Sabir JSM, Le Gras S, Stoll I, Albiheyri RS, Zari AT, Bahieldin A, Bellacosa A, Bronner C, Hamiche A
Lien Pubmed
Résumé
Inherited defects in the base-excision repair gene MBD4 predispose individuals to adenomatous polyposis and colorectal cancer, which is characterized by an accumulation of C > T transitions resulting from spontaneous deamination of 5'-methylcytosine.
Mots clés
Cancer, DNA methylation, MBD4, MLH1, Mismatch repair
Référence
J Exp Clin Cancer Res. 2023 11 14;42(1):301