In vitro stability study of 10 beta-lactam antibiotics in human plasma samples.
Fiche publication
Date publication
novembre 2023
Journal
Fundamental & clinical pharmacology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr JOUZEAU Jean-Yves
Tous les auteurs :
Brenkman M, Cartau T, Pape E, Kolodziej A, Charmillon A, Novy E, Jouzeau JY, Gambier N, Scala-Bertola J
Lien Pubmed
Résumé
Beta-lactam antibiotics are reported for some of them to be subject to a rapid degradation in infusion solutions and in human blood samples. However, the current data of stability available in blood samples are limited to a few number of beta-lactam antibiotics, and the methodology of the corresponding studies may be discussed. The objective of the present study is to evaluate the stability of 10 beta-lactam antibiotics in human plasma samples.
Mots clés
beta-lactams, drug monitoring, human plasma, quality assurance, stability
Référence
Fundam Clin Pharmacol. 2023 11 20;: