Counteracting tryptophan metabolism alterations as a new therapeutic strategy for rheumatoid arthritis.
Fiche publication
Date publication
novembre 2023
Journal
Annals of the rheumatic diseases
Auteurs
Membres identifiés du Cancéropôle Est :
Pr JOUZEAU Jean-Yves, Pr GOTTENBERG Jacques-Eric
Tous les auteurs :
Moulin D, Millard M, Taïeb M, Michaudel C, Aucouturier A, Lefèvre A, Bermúdez-Humarán LG, Langella P, Sereme Y, Wanherdrick K, Gautam P, Mariette X, Dieudé P, Gottenberg JE, Jouzeau JY, Skurnik D, Emond P, Mulleman D, Sellam J, Sokol H
Lien Pubmed
Résumé
Alterations in tryptophan (Trp) metabolism have been reported in inflammatory diseases, including rheumatoid arthritis (RA). However, understanding whether these alterations participate in RA development and can be considered putative therapeutic targets remains undetermined.In this study, we combined quantitative Trp metabolomics in the serum from patients with RA and corrective administration of a recombinant enzyme in experimental arthritis to address this question.
Mots clés
antirheumatic agents, inflammation, rheumatoid arthritis
Référence
Ann Rheum Dis. 2023 11 24;: