Synthesis, Hydrolytic Stability and In Vivo Biological Study of Bioconjugates of the Tetrapeptides FELL Containing Pyrrole Moiety.
Fiche publication
Date publication
décembre 2023
Journal
Biomedicines
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GERARD Stéphane, Dr COCHARD Marie
Tous les auteurs :
Borisova B, Vladimirova S, Nocheva H, Laronze-Cochard M, Gérard S, Petrin S, Danalev D
Lien Pubmed
Résumé
Bioconjugates are promising alternatives for the multiple targeting of any disease. Pyrrole heterocycle is well known with many activities and is a building block of a lot of medical drugs. On the other hand, peptides are short molecules with many advantages such as small size, ability to penetrate the cell membrane and bond-specific receptors, vectorizing potential, etc. Thus, hybrid molecules between peptide and pyrrole moiety could be a promising alternative as an anti-pain tool.
Mots clés
FELL, analgesic activity, bioconguates, hydrolytic stability, peptides, pyrrole
Référence
Biomedicines. 2023 12 9;11(12):