Amelioration of experimental autoimmune encephalomyelitis by in vivo reprogramming of macrophages using pro-resolving factors.
Fiche publication
Date publication
décembre 2023
Journal
Journal of neuroinflammation
Auteurs
Membres identifiés du Cancéropôle Est :
Dr PERRUCHE Sylvain
Tous les auteurs :
Gauthier T, Martin-Rodriguez O, Chagué C, Daoui A, Ceroi A, Varin A, Bonnefoy F, Valmary-Degano S, Couturier M, Behlke S, Saas P, Cartron PF, Perruche S
Lien Pubmed
Résumé
Reinstating inflammation resolution represents an innovative concept to regain inflammation control in diseases marked by chronic inflammation. While most therapeutics target inflammatory molecules and inflammatory effector cells and mediators, targeting macrophages to initiate inflammation resolution to control neuroinflammation has not yet been attempted. Resolution-phase macrophages are critical in the resolution process to regain tissue homeostasis, and are programmed through the presence and elimination of apoptotic leukocytes. Hence, inducing resolution-phase macrophages might represent an innovative therapeutic approach to control and terminate dysregulated neuroinflammation.
Mots clés
Epigenetic reprogramming, Macrophages, Neuroinflammation, Resolution of inflammation, Secretome
Référence
J Neuroinflammation. 2023 12 20;20(1):307