Dopamine precursor depletion affects performance and confidence judgements when events are timed from an explicit, but not an implicit onset.
Fiche publication
Date publication
décembre 2023
Journal
Scientific reports
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MUTTER Catherine
Tous les auteurs :
Jovanovic L, Chassignolle M, Schmidt-Mutter C, Behr G, Coull JT, Giersch A
Lien Pubmed
Résumé
Dopamine affects processing of temporal information, but most previous work has tested its role in prospective tasks, where participants know in advance when the event to be timed starts. However, we are often exposed to events whose onset we do not know in advance. We can evaluate their duration after they have elapsed, but mechanisms underlying this ability are still elusive. Here we contrasted effects of acute phenylalanine and tyrosine depletion (APTD) on both forms of timing in healthy volunteers, in a within-subject, placebo-controlled design. Participants were presented with a disc moving around a circular path and asked to reproduce the duration of one full revolution and to judge their confidence in performance. The onset of the revolution was either known in advance (explicit onset) or revealed only at the end of the trial (implicit onset). We found that APTD shortened reproduced durations in the explicit onset task but had no effect on temporal performance in the implicit onset task. This dissociation is corroborated by effects of APTD on confidence judgements in the explicit task only. Our findings suggest that dopamine has a specific role in prospective encoding of temporal intervals, rather than the processing of temporal information in general.
Référence
Sci Rep. 2023 12 11;13(1):21933