PhpC modulates G-quadruplex-RNA landscapes in human cells.
Fiche publication
Date publication
décembre 2023
Journal
Chemical communications (Cambridge, England)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MONCHAUD David, Dr VALVERDE Ibai
Tous les auteurs :
Mitteaux J, Raevens S, Wang Z, Pirrotta M, Valverde IE, Hudson RHE, Monchaud D
Lien Pubmed
Résumé
Stabilizing DNA/RNA G-quadruplexes (G4s) using small molecules (ligands) has proven an efficient strategy to decipher G4 biology. Quite paradoxically, this search has also highlighted the need for finding molecules able to disrupt G4s to tackle G4-associated cellular dysfunctions. We report here on both qualitative and quantitative investigations that validate the G4-RNA-destabilizing properties of the leading compound PhpC in human cells.
Référence
Chem Commun (Camb). 2023 12 12;: