Chronic morphine leaves a durable fingerprint on whole brain functional connectivity.
Fiche publication
Date publication
décembre 2023
Journal
Biological psychiatry
Auteurs
Membres identifiés du Cancéropôle Est :
Dr NOBLET Vincent, Dr DARCQ Emmanuel
Tous les auteurs :
Sourty M, Champagnol-Di Liberti C, Nasseef MT, Welsch L, Noblet V, Darcq E, Kieffer BL
Lien Pubmed
Résumé
Opioid use disorder (OUD) is a chronic relapsing disorder. The brain adapts to opioids along pain treatment or recreational use, so that abstinence becomes a true challenge for individuals with OUD. Studying brain dysfunction at this stage is difficult, and human neuroimaging provides highly heterogenous information.
Mots clés
amygdala, default mode network, functional Resonance Magnetic Imaging, morphine sensitivity, mouse model, network signature, opioid abstinence, opioid use disorder
Référence
Biol Psychiatry. 2023 12 15;: