Novel platform for subcutaneous tumor irradiation in mice.
Fiche publication
Date publication
juillet 2023
Journal
Methods in cell biology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MIRJOLET Céline, Dr BESSIERES Igor
Tous les auteurs :
Mirjolet C, Ladjohounlou R, Baude J, Bessières I
Lien Pubmed
Résumé
Preclinical development of cancer treatments including radiotherapy (RT) is now crucial to optimize all the treatment aspects for a better efficacy and to help clinicians to build new clinical trials based on robust results. More and more teams use preclinical irradiators to deliver radiotherapy in a comparable way to clinical treatments (image-based RT, arc therapy, stereotactic body RT…). In daily conditions, users usually need to develop easy to use techniques (for applicator technicians for example), allowing to treat many mice per day with a high level of reproducibility. Besides, the best compromise between a satisfying dose coverage to the tumor and nearby organs at risk sparing has to be ensured. We describe here new a home-made immobilization device to irradiate grafted tumors, as well as the different steps to develop the treatment planning and generate an easy procedure to routinely irradiate subcutaneous tumor model.
Mots clés
Easy procedure, Preclinical RT procedure, Radiation therapy, Subcutaneous tumor, in vivo model
Référence
Methods Cell Biol. 2023 07 19;180:69-80