Patient-derived lymphoma spheroids integrating immune tumor microenvironment as preclinical follicular lymphoma models for personalized medicine.
Fiche publication
Date publication
octobre 2023
Journal
Journal for immunotherapy of cancer
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ROSSI Cédric
Tous les auteurs :
Faria C, Gava F, Gravelle P, Valero JG, Dobaño-López C, Van Acker N, Quelen C, Jalowicki G, Morin R, Rossi C, Lagarde JM, Fournié JJ, Ysebaert L, Laurent C, Pérez-Galán P, Bezombes C
Lien Pubmed
Résumé
Follicular lymphoma (FL), the most common indolent non-Hodgkin's Lymphoma, is a heterogeneous disease and a paradigm of the contribution of immune tumor microenvironment to disease onset, progression, and therapy resistance. Patient-derived models are scarce and fail to reproduce immune phenotypes and therapeutic responses.
Mots clés
Hematologic Neoplasms, Immune Checkpoint Inhibitors, Immunotherapy, Tumor Microenvironment
Référence
J Immunother Cancer. 2023 10;11(10):