Anaplastic Lymphoma Kinase Inhibitor-Induced Neutropenia: A Systematic Review.
Fiche publication
Date publication
octobre 2023
Journal
Cancers
Auteurs
Membres identifiés du Cancéropôle Est :
Pr PETIT Thierry, Dr SCHOTT Roland, Dr DEMARCHI Martin, Dr BENDER Laura
Tous les auteurs :
Moinard-Butot F, Nannini S, Fischbach C, Abdallahoui S, Demarchi M, Petit T, Bender L, Schott R
Lien Pubmed
Résumé
Lung cancers with ALK rearrangement represent less than 5% of all lung cancers. ALK inhibitors are currently used to treat first-line metastatic non-small cell lung cancer with ALK rearrangement. Compared to chemotherapy, ALK inhibitors have improved progression-free survival, overall survival, and quality of life for patients. The results of several phase 3 studies with a follow-up of over 6 years suggest that the life expectancy of these patients treated with targeted therapies is significantly higher than 5 years and could approach 10 years. Nevertheless, these treatments induce haematological toxicities, including neutropenia. Few data are available on neutropenia induced by ALK inhibitors and on the pathophysiological mechanism and therapeutic adaptations necessary to continue the treatment. Given the high efficacy of these treatments, managing side effects to avoid treatment interruptions is essential. Here, we have reviewed the data from published clinical studies and case reports to provide an overview of neutropenia induced by ALK inhibitors.
Mots clés
ALK inhibitor, NSCLC, haematological toxicities, neutropenia
Référence
Cancers (Basel). 2023 10 11;15(20):