Polyploid Giant Cancer Cells Generated from Human Cytomegalovirus-Infected Prostate Epithelial Cells.
Fiche publication
Date publication
octobre 2023
Journal
Cancers
Auteurs
Membres identifiés du Cancéropôle Est :
Pr HERBEIN Georges
Tous les auteurs :
Bouezzedine F, El Baba R, Haidar Ahmad S, Herbein G
Lien Pubmed
Résumé
Prostate cancer is the most commonly diagnosed malignancy and the sixth leading cause of cancer death in men worldwide. Chromosomal instability (CIN) and polyploid giant cancer cells (PGCCs) have been considered predominant hallmarks of cancer. Recent clinical studies have proven the association of CIN, aneuploidy, and PGCCs with poor prognosis of prostate cancer (PCa). Evidence of HCMV transforming potential might indicate that HCMV may be involved in PCa.
Mots clés
CIN, PGCCs, high-risk HCMV strains, human cytomegalovirus, oncogenesis, prostate cancer, stemness
Référence
Cancers (Basel). 2023 10 15;15(20):