The Impact of COVID-19 on the Response to Hypoxia.
Fiche publication
Date publication
octobre 2023
Journal
High altitude medicine & biology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr POUSSEL Mathias
Tous les auteurs :
Louis A, Pröpper C, Savina Y, Tanne C, Duperrex G, Robach P, Zellner P, Doutreleau S, Boulet JM, Frey A, Pillard F, Pistea C, Poussel M, Thuet T, Richalet JP, Lecoq-Jammes F
Lien Pubmed
Résumé
Louis, Alexandre, Charlotte Pröpper, Yann Savina, Corentin Tanne, Guy Duperrex, Paul Robach, Pascal Zellner, Stéphane Doutreleau, Jean-Michel Boulet, Alain Frey, Fabien Pillard, Cristina Pistea, Mathias Poussel, Thomas Thuet, Jean-Paul Richalet, and François Lecoq-Jammes. The impact of COVID-19 on the response to hypoxia. 00:000-000, 2023. Severe high-altitude illness (SHAI) and coronavirus disease 2019 (COVID-19), while differing in most aspects of pathophysiology, both involve respiratory capacity. We examined the long-term impact of COVID-19 on response to hypoxia in individuals free of symptoms but having tested positive during the pandemic. The need for recommendations for such individuals planning a stay at high altitude are discussed. This multicenter study recruited participants from the multiSHAI cohort, all of whom had previously undergone a hypoxic exercise test. These participants were classified into two groups depending on whether they had since suffered mild-to-moderate COVID-19 (COVID+) or not (Control) and then asked to retake the test. Primary outcomes were: desaturation induced by hypoxia at exercise (ΔSpE), hypoxic cardiac response at exercise, hypoxic ventilatory response at exercise, and SHAI risk score. A total of 68 participants retook the test, 36 classified in the COVID+ group. Analyses of primary outcomes showed no significant differences between groups. However, the COVID+ group showed significantly increased ventilation (VE) parameters during both hypoxic ( = 0.003) and normoxic exercise ( = 0.007). However, only the VE/oxygen consumption relationship during hypoxic exercise was significantly different. This study demonstrates no negative impact of COVID-19 on response to hypoxia as evaluated by the Richalet test. NTC number: NCT05167357.
Mots clés
COVID-19, SHAI score, altitude, exercise, hypoxia
Référence
High Alt Med Biol. 2023 10 16;: