[Immune modulation with extracorporeal photopheresis in renal transplantation: proof of concept clinical outcomes and perspective].
Fiche publication
Date publication
octobre 2023
Journal
Nephrologie & therapeutique
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DUCLOUX Didier
Tous les auteurs :
Crépin T, Lionet A, Augusto JF, Hazzan M, Garrouste C, Heng AE, Ducloux D
Lien Pubmed
Résumé
For 30 years, photopheresis is used to treat graft versus host disease and heart or lung allograft rejection. In this review, we discuss the place of photopheresis in kidney transplantation both in prevention or treatment of rejection. Mechanisms of action in kidney transplantation are mainly based on results observed in graft versus host disease and in heart or lung transplantation. Photopheresis may induce innate and adaptive immunity changes with restauration of a favourable Th1/Th2 immune balance, an expansion of LT /LB reg subsets, and a local enrichment in IL-10. French national clinical and mechanistic studies are underway to define the place of photopheresis therapy in immunomodulation strategies in kidney transplantation.
Mots clés
renal transplant, photopheresis, regulatory T cell, antibody-mediated rejection
Référence
Nephrol Ther. 2023 10 17;19(6):1-11