A 16-year bicentric retrospective analysis of ovarian tissue cryopreservation in pediatric units: indications, results, and outcome.
Fiche publication
Date publication
août 2023
Journal
Frontiers in endocrinology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr AVEROUS Gerlinde, Dr TELETIN Marius, Dr DELEPINE Béatrice
Tous les auteurs :
Grellet-Grün M, Delepine B, Le Van Quyen P, Avérous G, Durlach A, Greze C, Ladureau-Fritsch L, Lichtblau I, Canepa AS, Liné A, Paillard C, Pluchart C, Pirrello O, Rongieres C, Harika G, Becmeur F, Teletin M
Lien Pubmed
Résumé
Cancer treatments of the last decades improve the survival rate of children and adolescents. However, chemo- and radiotherapy result in gonadal damage, leading to acute ovarian failure and sterility. The preservation of fertility is now an integral part of care of children requiring gonadotoxic treatments. Ovarian tissue cryopreservation (OTC) is an effective fertility preservation option that allows long-term storage of primordial follicles, subsequent transplantation, and restoration of endocrine function and fertility. The efficacy of this technique is well-demonstrated in adults but the data are scarce for pediatric patients. Currently, OTC represents the only possibility of preserving the potential fertility in prepubertal girls.
Mots clés
children cancer, fertility preservation, follow up, gonadotoxic treatment, ovarian tissue cryopreservation
Référence
Front Endocrinol (Lausanne). 2023 08 31;14:1158405