MUC13 Cell Surface Mucin Limits Salmonella Typhimurium Infection by Protecting the Mucosal Epithelial Barrier.
Fiche publication
Date publication
septembre 2023
Journal
Cellular and molecular gastroenterology and hepatology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr OUSSALAH Abderrahim
Tous les auteurs :
McGuckin MA, Davies JM, Felgner P, Wong KY, Giri R, He Y, Moniruzzaman M, Kryza T, Sajiir H, Hooper JD, Florin TH, Begun J, Oussalah A, Hasnain SZ, Hensel M, Sheng YH
Lien Pubmed
Résumé
MUC13 cell surface mucin is highly expressed on the mucosal surface throughout the intestine, yet its role against bacterial infection is unknown. We investigated how MUC13 impacts Salmonella Typhimurium (S. Tm) infection and elucidated its mechanisms of action.
Mots clés
MUC13, Salmonella, adhesion, bacterial invasion, cell death, epithelial cell, intestinal barrier, mucin
Référence
Cell Mol Gastroenterol Hepatol. 2023 09 1;: