Transcriptomic integrity of human oocytes used in ARTs: technical and intrinsic factor effects.
Fiche publication
Date publication
septembre 2023
Journal
Human reproduction update
Auteurs
Membres identifiés du Cancéropôle Est :
Pr FAUQUE Patricia
Tous les auteurs :
Ducreux B, Patrat C, Trasler J, Fauque P
Lien Pubmed
Résumé
Millions of children have been born throughout the world thanks to ARTs, the harmlessness of which has not yet been fully demonstrated. For years, efforts to evaluate the specific effects of ART have focused on the embryo; however, it is the oocyte quality that mainly dictates first and foremost the developmental potential of the future embryo. Ovarian stimulation, cryopreservation, and IVM are sometimes necessary steps to obtain a mature oocyte, but they could alter the appropriate expression of the oocyte genome. Additionally, it is likely that female infertility, environmental factors, and lifestyle have a significant influence on oocyte transcriptomic quality, which may interfere with the outcome of an ART attempt.
Mots clés
IVF, RNA-seq, assisted reproduductive technologies, human oocyte, transcriptome
Référence
Hum Reprod Update. 2023 09 11;: