Accelerated aging in bipolar disorders: An exploratory study of six epigenetic clocks.
Fiche publication
Date publication
juillet 2023
Journal
Psychiatry research
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LUTZ Pierre-Eric
Tous les auteurs :
Bourdon C, Etain B, Spano L, Belzeaux R, Leboyer M, Delahaye-Duriez A, Ibrahim EC, Lutz PE, Gard S, Schwan R, Polosan M, Courtet P, Passerieux C, Bellivier F, Marie-Claire C
Lien Pubmed
Résumé
Bipolar disorder (BD) is a chronic and severe psychiatric disorder associated with significant medical morbidity and reduced life expectancy. In this study, we assessed accelerated epigenetic aging in individuals with BD using various DNA methylation (DNAm)-based markers. For this purpose, we used five epigenetic clocks (Horvath, Hannum, EN, PhenoAge, and GrimAge) and a DNAm-based telomere length clock (DNAmTL). DNAm profiles were obtained using Infinium MethylationEPIC Arrays from whole-blood samples of 184 individuals with BD. We also estimated blood cell counts based on DNAm levels for adjustment. Significant correlations between chronological age and each epigenetic age estimated using the six different clocks were observed. Following adjustment for blood cell counts, we found that the six epigenetic AgeAccels (age accelerations) were significantly associated with the body mass index. GrimAge AgeAccel was significantly associated with male sex, smoking status and childhood maltreatment. DNAmTL AgeAccel was significantly associated with smoking status. Overall, this study showed that distinct epigenetic clocks are sensitive to different aspects of aging process in BD. Further investigations with comprehensive epigenetic clock analyses and large samples are required to confirm our findings of potential determinants of an accelerated epigenetic aging in BD.
Mots clés
Age acceleration, Bipolar disorder, DNA methylation, Epigenetic age
Référence
Psychiatry Res. 2023 07 26;327:115373