Polymyxin B complexation enhances the antimicrobial potential of graphene oxide.
Fiche publication
Date publication
juin 2023
Journal
Frontiers in cellular and infection microbiology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BIANCO Alberto
Tous les auteurs :
Pandit S, Jacquemin L, Zhang J, Gao Z, Nishina Y, Meyer RL, Mijakovic I, Bianco A, Pang C
Lien Pubmed
Résumé
The antibacterial activity of graphene oxide (GO) has been widely explored and tested against various pathogenic bacterial strains. Although antimicrobial activity of GO against planktonic bacterial cells was demonstrated, its bacteriostatic and bactericidal effect alone is not sufficient to damage sedentary and well protected bacterial cells inside biofilms. Thus, to be utilized as an effective antibacterial agent, it is necessary to improve the antibacterial activity of GO either by integration with other nanomaterials or by attachment of antimicrobial agents. In this study, antimicrobial peptide polymyxin B (PMB) was adsorbed onto the surface of pristine GO and GO functionalized with triethylene glycol.
Mots clés
adhesion, antibiotics, antimicrobial peptide, bacteria, biofilm, carbon materials
Référence
Front Cell Infect Microbiol. 2023 06 21;13:1209563