Glioblastoma Metabolism: Insights and Therapeutic Strategies.
Fiche publication
Date publication
mai 2023
Journal
International journal of molecular sciences
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DONTENWILL Monique, Pr ENTZ-WERLE Natacha, Dr MARTIN Sophie, Dr REITA Damien
Tous les auteurs :
Bernhard C, Reita D, Martin S, Entz-Werle N, Dontenwill M
Lien Pubmed
Résumé
Tumor metabolism is emerging as a potential target for cancer therapies. This new approach holds particular promise for the treatment of glioblastoma, a highly lethal brain tumor that is resistant to conventional treatments, for which improving therapeutic strategies is a major challenge. The presence of glioma stem cells is a critical factor in therapy resistance, thus making it essential to eliminate these cells for the long-term survival of cancer patients. Recent advancements in our understanding of cancer metabolism have shown that glioblastoma metabolism is highly heterogeneous, and that cancer stem cells exhibit specific metabolic traits that support their unique functionality. The objective of this review is to examine the metabolic changes in glioblastoma and investigate the role of specific metabolic processes in tumorigenesis, as well as associated therapeutic approaches, with a particular focus on glioma stem cell populations.
Mots clés
cancer stem cells, glioblastoma, metabolism, therapy, tumorigenic processes
Référence
Int J Mol Sci. 2023 05 23;24(11):