Resolved psoriasis with abundant oleic acid in stratum corneum exhibits lower T-cell-driven IL-17 signature.
Fiche publication
Date publication
mai 2023
Journal
The Journal of investigative dermatology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr AUBIN François, Dr PAIS DE BARROS Jean-Paul
Tous les auteurs :
El Mahi Y, Varin A, Vetter M, Zuffo LD, Mazzeo L, Païs De Barros JP, Aubin F, Saas P, Sérézal IG
Lien Pubmed
Résumé
Relapses of psoriasis involve T cells that stem and survive in the skin. Inherited from previous flares, the tissue-resident memory T cells are epidermal IL-17-producing CD8 and IL-22-producing CD4 T cells. Since the capacity of resident memory T cells to intake fatty acids is essential for their residence and function, that the surface composition of fatty acids may affect underlying T cell populations. In patients treated with biologics, we used gas chromatography/mass spectrometry (GC/MS) to decipher the fatty acid composition in both resolved and non-lesional sites. Skin T cells were activated by OKT-3 in explants from the same body sites to perform bulk transcriptomic analysis (Nanostring). The fatty acid composition differed between skin from healthy donors and normal-looking skin of psoriasis patients, but not further between non-lesional and resolved skin. Patients in whom the resolved skin was rich in oleic acid had lower T-cell-driven IL-17 epidermal transcriptomic signature upon activation of T cells in skin explants. The skin lipid composition is linked with functions of the underlying epidermal T cells. Testing the modulating effect of custom fatty-acids on skin resident T cells could help coming closer to disease oblivion in inflammatory skin diseases.
Référence
J Invest Dermatol. 2023 05 17;: