Androgen receptor coordinates muscle metabolic and contractile functions.
Fiche publication
Date publication
mai 2023
Journal
Journal of cachexia, sarcopenia and muscle
Auteurs
Membres identifiés du Cancéropôle Est :
Dr METZGER Daniel, Mme MESSADDEQ Nadia
Tous les auteurs :
Ghaibour K, Schuh M, Souali-Crespo S, Chambon C, Charlot A, Rizk J, Rovito D, Rerra AI, Cai Q, Messaddeq N, Zoll J, Duteil D, Metzger D
Lien Pubmed
Résumé
Androgens are anabolic steroid hormones that exert their function by binding to the androgen receptor (AR). We have previously established that AR deficiency in limb muscles impairs sarcomere myofibrillar organization and decreases muscle strength in male mice. However, despite numerous studies performed in men and rodents, the signalling pathways controlled by androgens via their receptor in skeletal muscles remain poorly understood.
Mots clés
androgen receptor, genomics, metabolism, skeletal muscle, type 2 diabetes
Référence
J Cachexia Sarcopenia Muscle. 2023 05 20;: