[18F]F-Choline PET/CT and 4D-CT in the evaluation of primary hyperparathyroidism: rivals or allies?
Fiche publication
Date publication
juin 2023
Journal
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...
Auteurs
Membres identifiés du Cancéropôle Est :
Pr IMPERIALE Alessio
Tous les auteurs :
Fiz F, Bottoni G, Massollo M, Trimboli P, Catrambone U, Bacigalupo L, Righi S, Treglia G, Imperiale A, Piccardo A
Lien Pubmed
Résumé
Primary hyperparathyroidism is a hard-to-diagnose condition that can run without symptoms for many years without causing symptoms; yet, it can cause dire long-term consequences, such as osteoporosis and renal impairment. First-line diagnostic methods include ultrasound and parathyroid scintigraphy, which provide unsatisfactory results in terms of detection rate. Second-line imaging methods include [F]F-Choline PET/CT, 4D-CT, and their combination. These methods have shown a great detection rate and sensitivity; however, they are to this day less widespread than the first-line ones. Both the two methods (PET and 4D-CT) have their specific advantages and field of application, as well as their specific limitations. In this narrative review, we will describe the advantages and disadvantages of the two techniques extensively. Moreover, we will try to identify whether the combined examination can play a role and how relevant this role is. Finally, we will try to define the specific clinical situation in which each method can provide the best contribution to diagnosing parathyroid tissue hyperfunction.
Mots clés
Humans, Positron Emission Tomography Computed Tomography, methods, Hyperparathyroidism, Primary, diagnostic imaging, Four-Dimensional Computed Tomography, Choline, Parathyroid Glands, diagnostic imaging, Technetium Tc 99m Sestamibi
Référence
Q J Nucl Med Mol Imaging. 2023 06;67(2):130-137