In vivo validation of Ga-labeled AMD3100 conjugates for PET imaging of CXCR4.
Fiche publication
Date publication
avril 2023
Journal
Nuclear medicine and biology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DENAT Franck
Tous les auteurs :
Renard I, Domarkas J, Poty S, Burke BP, Roberts DP, Goze C, Denat F, Cawthorne CJ, Archibald SJ
Lien Pubmed
Résumé
The chemokine receptor CXCR4 has been shown to be over-expressed in multiple types of cancer and is usually associated with aggressive phenotypes and poor prognosis. Successfully targeting and imaging the expression level of this receptor in tumours could inform treatment selection and facilitate patient stratification.
Mots clés
AMD3100, CXCR4, Chemokine receptor, Gallium-68, PET
Référence
Nucl Med Biol. 2023 04 5;120-121:108335