Discriminating young platelets on human leukocyte antigen-I expression highlights their extremely high reactivity potential.
Fiche publication
Date publication
janvier 2023
Journal
Research and practice in thrombosis and haemostasis
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MANGIN Pierre
Tous les auteurs :
Angénieux C, Couvidou A, Brouard N, Eckly A, Dupuis A, Mangin PH, Maître B
Lien Pubmed
Résumé
The platelet population is heterogeneous, with different subsets that differ on the basis of their function and reactivity. An intrinsic factor participating in this difference of reactivity could be the platelet age. The lack of relevant tools allowing a formal identification of young platelets prevents so far to draw solid conclusions regarding platelet reactivity. We recently reported that human leukocyte antigen-I (HLA-I) molecules are more expressed on human young platelets.
Mots clés
COAT, COllagen And Thrombin activated, CRP, Collagen Related Peptide, Conv, Convulxin, FC, Flow Cytometry, HLA-I, Human Leukocyte Antigen-I, P ribo prot, Anti-ribosomal P protein, TO, Thiazole orange, TRAP, Thrombin receptor activating peptide, electron microscopy, fluorescence-activated cell sorting, human class I antigens, platelets, procoagulant, vWF, Von Willebrand factor
Référence
Res Pract Thromb Haemost. 2023 01;7(1):100006