The Mechanism of Action of SAAP-148 Antimicrobial Peptide as Studied with NMR and Molecular Dynamics Simulations.
Fiche publication
Date publication
février 2023
Journal
Pharmaceutics
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BECHINGER Burkhard
Tous les auteurs :
Adélaïde M, Salnikov E, Ramos-Martín F, Aisenbrey C, Sarazin C, Bechinger B, D'Amelio N
Lien Pubmed
Résumé
SAAP-148 is an antimicrobial peptide derived from LL-37. It exhibits excellent activity against drug-resistant bacteria and biofilms while resisting degradation in physiological conditions. Despite its optimal pharmacological properties, its mechanism of action at the molecular level has not been explored.
Mots clés
NMR, antimicrobial, biomembranes, membrane topology, molecular dynamics, paramagnetic relaxation enhancement, peptides, solid-state NMR spectroscopy
Référence
Pharmaceutics. 2023 02 24;15(3):