Mechanical Characterization of 3D-Printed Patterned Membranes for Cardiac Tissue Engineering: An Experimental and Numerical Study.
Fiche publication
Date publication
mars 2023
Journal
Biomedicines
Auteurs
Membres identifiés du Cancéropôle Est :
Dr CLEYMAND Franck, Pr MANO João F.
Tous les auteurs :
Poerio A, Guibert B, Leroux MM, Mano JF, Cleymand F, Jehl JP
Lien Pubmed
Résumé
A myocardial infarction can cause irreversible damage to the heart muscle. A promising approach for the treatment of myocardial infarction and prevention of severe complications is the application of cardiac patches or epicardial restraint devices. The challenge for the fabrication of cardiac patches is the replication of the fibrillar structure of the myocardium, in particular its anisotropy and local elasticity. In this study, we developed a chitosan-gelatin-guar gum-based biomaterial ink that was fabricated using 3D printing to create patterned anisotropic membranes. The experimental results were then used to develop a numerical model able to predict the elastic properties of additional geometries with tunable elasticity that could easily match the mechanical properties of the heart tissue (particularly the myocardium).
Mots clés
3D bioprinting, biomaterials, cardiac membrane, mechanical behavior, numerical simulation, tissue engineering
Référence
Biomedicines. 2023 03 21;11(3):