Neurotensin and Its Involvement in Reproductive Functions: An Exhaustive Review of the Literature.
Fiche publication
Date publication
février 2023
Journal
International journal of molecular sciences
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GAUCHOTTE Guillaume
Tous les auteurs :
Arbogast P, Gauchotte G, Mougel R, Morel O, Ziyyat A, Agopiantz M
Lien Pubmed
Résumé
Neurotensin (NTS) is a peptide discovered in 1973, which has been studied in many fields and mainly in oncology for its action in tumor growth and proliferation. In this review of the literature, we wanted to focus on its involvement in reproductive functions. NTS participates in an autocrine manner in the mechanisms of ovulation via NTS receptor 3 (NTSR3), present in granulosa cells. Spermatozoa express only its receptors, whereas in the female reproductive system (endometrial and tube epithelia and granulosa cells), we find both NTS secretion and the expression of its receptors. It consistently enhances the acrosome reaction of spermatozoa in mammals in a paracrine manner via its interaction with NTSR1 and NTSR2. Furthermore, previous results on embryonic quality and development are discordant. NTS appears to be involved in the key stages of fertilization and could improve the results of in vitro fertilization, especially through its effect on the acrosomal reaction.
Mots clés
acrosome reaction, fertilization, neurotensin, ovulation, reproduction, spermatozoa
Référence
Int J Mol Sci. 2023 02 27;24(5):